Skyscape works on Pre with the Classic thing [motionapps.com/classic]. They have a couple of products set up for that. I did 5mcc and a drug reference. Very slow to install, but once there it works great. As fast and usable as on my old TX. Faster, actually.
The smart link works great too. You have to do a manual unlock (like on the Mac/Palm according to a collegue), but that is no big deal.
Even Skyscape now list Palm Pre as an option in their product pages